Pulsatile Microdialysis (PMD)

What is PMD?

PMD is an innovative technology that is owned by Physical Pharmaceutica, which offers unique characterization and analytical capabilities that are not available with other technologies. Over 15 years of research and development have led to five awarded patents and unique, leading edge technical expertise that is at the forefront of studying drug release from complex systems (nanoparticles, microemulsions, liposomes, and others) and the fate of supersaturated drug solutions (the dissolved free concentration . 

 

PMD provides accurate and reproducible data, and is used to determine the dissolved free drug concentration in media. It is particularly advantageous for performing studies of systems that are heterogeneous on the micro and macro scales, can be implanted in systems for in situ sampling. For many systems, PMD provides data that no other technology can provide. For instance, drug concentrations in complex media can be determined as often as every 15 seconds, which is a time resolution that is unmatched by any other technology. 

 

Applications of PMD

 

PMD has been used to study dozens of systems, including:

  • in vitro dissolution sampling of nanoparticles and supersaturating dosage forms to determine free dissolved drug concentrations over time (which represent the absorbable form of the drug), including spring and parachute patterns
  • Nucleation and precipitation kinetics from supersaturated solutions
  • Release of drugs from microemulsions, micelles and liposomes
  • drug distribution in microscopically multiphasic systems such as microemulsions, micelles and liposomes
  • in situ solubility studies to assess the effects of excipients such as polymers, sodium chloride, sucrose, etc. on the solubility of poorly soluble drugs in aqueous solutions
  • in situ drug distribution studies to determine the drug distribution in creams and gels
  • Solubility studies to assess the effects of excipients such as polymers, sodium chloride, sucrose, etc. on the solubility of poorly soluble drugs in aqueous solutions
  • Kinetics of drug binding and release to proteins and other carriers
  • Determination of drug transport properties and parameters
Print Print | Sitemap
© Physical Pharmaceutica, LLC