Our Services


 Physical Pharmaceutica strives to provide the best expertise, innovation and service. Count on us for both basic and unique, specialized solutions. 


 Excipient screening for supersaturating formulations

  • Mimic dissolution patterns and screen for polymers and excipients that will provide the optimal "spring & parachute" for enhanced bioavailability
  • Screen in any medium, helps to predict performance in the GI fluids
  • Perfect add-on to solid-state screening (polymorph screening does not adequately predict dissolution and precipitation)
  • First test of its kind in the industry  


 In vitro dissolution and in vitro release test (IVRT) development

  • Dissolution and release from nanoparticles and amorphous solid dispersions
  • Amorphous solid dispersion dissolution
  • Drug release rates from microemulsions and ophthalmic emulsions
  • Drug release from semi-solid formulations (creams, ointments, gels)
  • Drug release and leakage from liposomes


 In  vitro release rate testing services

  • Drug release kinetics from ophthalmic emulsions, with release data obtained in the first 30 seconds (not extrapolated from later times)
  • Supersaturation, spring and parachute patterns, and precipitation kinetics
  • Drug release from semi-solids (formulation development and SUPAC)
  • Extended transdermal drug permeation experiments designed to avoid skin breakdown from prolonged exposure to liquid receiving media  


 Drug distribution in formulations

  • Microemulsions and ophthalmic emulsions (globule vs. aqueous phases)
  • Semi-solid (creams and gels) partitioning and binding
  • Liposomes  


 Data analysis and consulting

  • Expert data analysis that goes beyond the capability of your instrument's software or standard commercial packages
  • Custom physical and mathematical models
  • Biopharmaceutics and pharmacokinetic modeling
  • Determine absorption rates for orally administered drugs that are not well modeled by Wagner-Nelson or Loo-Riegelman
  • IVIVC (in vitro in vivo correlations)  
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