Physical Pharmaceutica strives to provide the best expertise, innovation and service. Count on us for both basic and unique, specialized
solutions.
Excipient screening for supersaturating formulations
- Mimic dissolution patterns and screen for polymers and excipients that will
provide the optimal "spring & parachute" for enhanced bioavailability
- Screen in any medium, helps to predict performance in the GI
fluids
- Perfect add-on to solid-state screening (polymorph screening does not
adequately predict dissolution and precipitation)
- First test of its kind in the industry
In vitro dissolution and in
vitro release test (IVRT) development
-
Dissolution and release from nanoparticles and amorphous solid dispersions
-
Amorphous solid dispersion dissolution
-
Drug release rates from microemulsions and ophthalmic emulsions
-
Drug release from semi-solid formulations (creams, ointments, gels)
-
Drug release and leakage from liposomes
In vitro release rate testing services
-
Drug release kinetics from ophthalmic emulsions, with release data obtained in the first 30 seconds (not extrapolated from later
times)
-
Supersaturation, spring and parachute patterns, and precipitation kinetics
-
Drug release from semi-solids (formulation development and SUPAC)
-
Extended transdermal drug permeation experiments designed to avoid skin breakdown from prolonged exposure to liquid receiving media
Drug distribution in formulations
-
Microemulsions and ophthalmic emulsions (globule vs. aqueous phases)
-
Semi-solid (creams and gels) partitioning and binding
-
Liposomes
Data analysis and consulting
-
Expert data analysis that goes beyond the capability of your instrument's software or standard commercial packages
-
Custom physical and mathematical models
-
Biopharmaceutics and pharmacokinetic modeling
-
Determine absorption rates for orally administered drugs that are not well modeled by Wagner-Nelson or Loo-Riegelman
-
IVIVC (in vitro in vivo correlations)