Our Services

 Physical Pharmaceutica strives to provide the best expertise, innovation and service. Count on us for both basic and unique, specialized solutions. 

 Excipient screening for supersaturating formulations

• Mimic dissolution patterns and screen for polymers and excipients that will provide the optimal "spring & parachute" for enhanced bioavailability
• Screen in any medium, helps to predict performance in the GI fluids
• Perfect add-on to solid-state screening (polymorph screening does not adequately predict dissolution and precipitation)
• First test of its kind in the industry  

 In vitro dissolution and in vitro release test (IVRT) development

• Dissolution and release from nanoparticles and amorphous solid dispersions
• Amorphous solid dispersion dissolution
• Drug release rates from microemulsions and ophthalmic emulsions
• Drug release from semi-solid formulations (creams, ointments, gels)
• Drug release and leakage from liposomes

 In  vitro release rate testing services

• Drug release kinetics from ophthalmic emulsions, with release data obtained in the first 30 seconds (not extrapolated from later times)
• Supersaturation, spring and parachute patterns, and precipitation kinetics
• Drug release from semi-solids (formulation development and SUPAC)
• Extended transdermal drug permeation experiments designed to avoid skin breakdown from prolonged exposure to liquid receiving media  

 Drug distribution in formulations

• Microemulsions and ophthalmic emulsions (globule vs. aqueous phases)
• Semi-solid (creams and gels) partitioning and binding
• Liposomes